Nerve-specific, xenogeneic extracellular matrix hydrogel promotes recovery following peripheral nerve injury
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چکیده
منابع مشابه
Edaravone promotes functional recovery after mechanical peripheral nerve injury
Edaravone has been shown to reduce ischemia/reperfusion-induced peripheral nerve injury. However, the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical factors is unknown. In the present study, we established a peripheral nerve injury model by crushing the sciatic nerve using hemostatic forceps, and then administered edaravone 3 mg/kg intraperitoneally. The sciatic...
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BACKGROUND AND PURPOSE EPO has been shown to have beneficial effects in a variety of CNS injury models. The purpose of this study was to evaluate the effects of EPO on nerve regeneration and functional recovery in a rat model of peripheral nerve surgery. MATERIALS AND METHODS The sciatic nerve of the rat with a 10-mm defect was bridged with a silicone rubber tube. Forty adult male Sprague-Daw...
متن کاملErythropoietin enhanced recovery after peripheral nerve injury
Peripheral nerve injuries are common disorders affecting the US population and represent a great economic and social burden. Acute injuries to peripheral nerves are most often due to an acute trauma or iatrogenic injury, with the resultant neurological deficit dependent on the injury type and severity. Clinical manifestations include a variable degree of motor and/or sensory deficits, with comp...
متن کاملIn vivo nerve-macrophage interactions following peripheral nerve injury.
In vertebrates, the peripheral nervous system has retained its regenerative capacity, enabling severed axons to reconnect with their original synaptic targets. While it is well documented that a favorable environment is critical for nerve regeneration, the complex cellular interactions between injured nerves with cells in their environment, as well as the functional significance of these intera...
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Damage to peripheral nerve tissue may cause loss of function in both the nerve and the targeted muscles it innervates. This study compared the repair capability of engineered nerve conduit (ENC), engineered fibroblast conduit (EFC), and autograft in a 10-mm tibial nerve gap. ENCs were fabricated utilizing primary fibroblasts and the nerve cells of rats on embryonic day 15 (E15). EFCs were fabri...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research Part A
سال: 2017
ISSN: 1549-3296
DOI: 10.1002/jbm.a.36235